Loftair Inhaler 110 Mcg 50 Mcg

What Is Loftair Inhaler 110 Mcg/50 Mcg?

• Patients stepping up from a low-dose ICS alone (such as 50 or 100 mcg Fluticasone) who still experience breakthrough symptoms
• Those transitioning from separate ICS and LABA inhalers to a single, simplified combination device
• Patients requiring moderate corticosteroid coverage combined with long-acting bronchodilation to achieve and maintain asthma control

Loftair 110/50 Composition: How Fluticasone and Salmeterol Work Together

Fluticasone Propionate 110 mcg — Inhaled Corticosteroid (ICS)

Salmeterol Xinafoate 50 mcg — Long-Acting Beta-2 Agonist (LABA)

Why the Fluticasone and Salmeterol Combination Works Better Than Either Drug Alone

• Salmeterol activates beta-2 receptors that enhance the nuclear translocation of glucocorticoid receptor complexes, amplifying the anti-inflammatory gene-silencing effect of Fluticasone beyond what Fluticasone would achieve on its own at the same dose.
• Fluticasone upregulates the expression of beta-2 adrenergic receptors on airway smooth muscle cells — preventing the receptor downregulation (tachyphylaxis) that would otherwise reduce Salmeterol's bronchodilatory effectiveness over time.
• Together, they address both the structural (inflammatory) and the functional (bronchoconstriction) components of airway disease — the two pillars of both asthma and COPD pathophysiology.

What Is Loftair Inhaler 110 Mcg/50 Mcg Used For?

Asthma Maintenance — Adults and Adolescents Aged 12 and Above

COPD Maintenance and Exacerbation Reduction

How to Use Loftair Inhaler 110 Mcg/50 Mcg — Correct pMDI Technique

Priming Before First Use

• Before using a new Loftair inhaler for the first time, prime it by shaking vigorously for 5 seconds, then releasing 4 test sprays into the air (away from face). This charges the valve with the correct suspension.
• Re-prime with 2 sprays if the inhaler has not been used for 4 or more days — shake for 5 seconds before priming. Failure to re-prime delivers an inaccurate first dose.

Each Dose — Step by Step

• Remove the mouthpiece cap and inspect the opening for blockages or debris
• Shake the inhaler vigorously for 5 full seconds — this redistributes the drug suspension for a consistent dose
• Hold the inhaler upright with your index finger on top of the canister and your thumb supporting the base
• Breathe out slowly and fully away from the inhaler — exhale as completely as comfortable
• Place the mouthpiece between your teeth and seal your lips around it firmly — do not bite
• Begin inhaling slowly and steadily through your mouth, then press the top of the canister down firmly once — continue inhaling slowly for 3 to 5 seconds after pressing
• Remove the inhaler from your mouth and hold your breath for 10 seconds before exhaling slowly
• If a second puff is needed, wait 30 seconds, shake again for 5 seconds, and repeat
• Always rinse your mouth thoroughly with water after use — spit without swallowing — to reduce the risk of oral thrush from deposited Fluticasone

Using a Spacer Device

Loftair 110/50 Mcg Dosage

• Adults and adolescents (12 years and above) — asthma: 2 inhalations twice daily (morning and evening), 12 hours apart; total daily dose: 440 mcg Fluticasone / 200 mcg Salmeterol
• Adults — COPD maintenance: 2 inhalations of the 110/50 mcg strength twice daily — check prescriber guidance as COPD dosing varies by guideline
• Elderly patients: No dose adjustment required, but monitor for cardiovascular effects and assess for osteoporosis risk with prolonged use
• Children under 12: The 100 mcg/50 mcg strength may be considered for children aged 4 to 11; the 110 mcg strength is not approved for this age group

Side Effects of Loftair Inhaler 110 Mcg/50 Mcg

Common Side Effects

• Upper respiratory tract infections including common cold and sinusitis — the most frequently reported
• Throat irritation, hoarseness, and dysphonia (voice changes)
• Oral candidiasis — prevented by rinsing the mouth after every dose
• Headache and dizziness
• Palpitations — awareness of heartbeat due to Salmeterol's beta-2 stimulation
• Tremor — fine trembling of the hands, usually mild and transient
• Muscle cramps and joint pain
• Nausea and indigestion
• Increased risk of pneumonia in COPD patients — monitor for chest infection symptoms

Serious Side Effects — Seek Immediate Medical Attention

• Paradoxical bronchospasm — sudden severe worsening of breathing immediately after inhalation; stop use and use rescue bronchodilator
• Severe allergic reaction (anaphylaxis): hives, facial or tongue swelling, throat tightening, difficulty breathing
• Rapid, irregular, or dangerously fast heartbeat — particularly at higher than prescribed doses
• Adrenal insufficiency with long-term use: extreme fatigue, nausea, weakness, fainting
• Severe hypokalaemia (low potassium): muscle weakness, cramps, cardiac arrhythmia — risk increases when used with diuretics, theophylline, or systemic corticosteroids

Who Should Not Use Loftair Inhaler 110 Mcg/50 Mcg?

• Patients with known hypersensitivity to Fluticasone Propionate, Salmeterol Xinafoate, lactose monohydrate (the carrier excipient — significant for patients with milk protein allergy), or HFA propellants
• As primary treatment of status asthmaticus or acute severe asthma requiring emergency hospitalisation
• Patients currently using another LABA-containing product (Formoterol, Arformoterol, Indacaterol, Olodaterol, Vilanterol) — dual LABA therapy dramatically increases cardiovascular risk
• Children under 4 years of age; the 110 mcg strength is not recommended under 12 years

How to Store Loftair Inhaler 110 Mcg/50 Mcg

• Store at controlled room temperature: 15°C to 30°C (59°F to 86°F)
• Store with the mouthpiece facing downward to maintain suspension integrity
• Protect from extreme heat — canister pressure may increase dangerously above 49°C; never leave in a closed vehicle, near radiators, or in direct sunlight
• Do not puncture, incinerate, or expose the pressurised canister to flames — even when empty
• Keep away from moisture — never rinse the metal canister with water
• Replace the mouthpiece cap firmly after every use to keep the actuator clean and prevent accidental actuation
• Keep out of reach of children
• Check the dose counter regularly — replace the inhaler before it runs out rather than continuing to use an empty canister that delivers only propellant without drug

Where to Buy Loftair Inhaler 110 Mcg/50 Mcg Online